Lactose intolerance is usually the result of a lactase deficiency. Lactase is an enzyme (a protein that causes a chemical reaction to occur) that is normally produced in your small intestine. If you have a lactase deficiency it means that your body does not produce enough lactase.
Digesting lactose
After eating or drinking something that contains lactose, it passes down your oesophagus (gullet) and into your stomach, where it is digested. The digested food then passes into your small intestine.
The lactase in your small intestine should break down the lactose into glucose and galactose (another type of sugar), which are then absorbed into your bloodstream. If there is not enough lactase, the unabsorbed lactose moves through your digestive system to your colon (your large intestine).
Bacteria in the colon ferment (react to) the lactose, producing fatty acids and gases such as carbon dioxide, hydrogen and methane. The reaction of the lactose in the colon, and the resulting acids and gases that are produced, cause the symptoms of lactose intolerance.
The main types of lactase deficiency are outlined below.
Primary lactase deficiency
Primary lactase deficiency is the most common cause of lactose intolerance. This type of lactase deficiency is genetically inherited (it runs in families) and usually develops between the ages of two and 20.
Primary lactase deficiency develops when your lactase production decreases as a result of your diet being less reliant on milk and dairy products. This is usually after the age of two, when breastfeeding or bottle-feeding has stopped, although the symptoms may not be noticeable until several years later.
Secondary lactase deficiency
Secondary lactase deficiency is a shortage of lactase that is caused by a problem in your small intestine. It can occur at any age, and may be the result of another condition, surgery to your small intestine or it can be caused by some medications.
Possible causes of secondary lactase deficiency include:
- coeliac disease, a bowel condition that is caused by an intolerance to a protein called gluten
- gastroenteritis, an infection of the stomach and intestines
- Crohn's disease, a chronic (long-term) condition that causes inflammation of the lining of the digestive system)
- ulcerative colitis, a long-term condition that affects the large intestine
- chemotherapy, a treatment for cancer
- long courses of antibiotics (medicines to treat infections caused by bacteria)
Certain conditions and treatments can cause a decrease in the production of lactase. Sometimes the deficiency is temporary, but if it is caused by a long-term condition it may be permanent.
It is also possible to develop secondary lactase deficiency later in life, even without another condition to trigger it. This is because your body’s production of lactase naturally reduces as you get older.
Congenital lactase deficiency
Congenital lactase deficiency is a rare condition that runs in families and is found in newborn babies.
A faulty gene (a unit of genetic material that determines your body's characteristics) results in little or no lactase being produced. The faulty gene is passed on from both your mother and father. This is known as an autosomal recessive trait.
Familial lactase deficiency
Familial lactase deficiency is similar to congenital lactase deficiency, and is also found in newborn babies. However, with this type of lactase deficiency, your body is able to produce a substantial amount of lactase, but the enzyme does not work and cannot break down the lactose.
As with congenital lactase deficiency, the faulty gene responsible for the production of lactase is passed on from both your mother and father.
Blood
Blood supplies oxygen to the body and removes carbon dioxide. It is pumped around the body by the heart.
Enzymes
Enzymes are proteins that speed up and control chemical reactions, such as digestion, in the body.
Intestines
The intestines are the part of the digestive system between the stomach and the anus that digests and absorbs food and liquid.
Bacteria
Bacteria are tiny, single-celled organisms that live in the body. Some can cause illness and disease and some are good for you.
Genetic
Genetic is a term that refers to genes. Genes are the characteristics inherited from a family member.
Gene
A gene is a unit of genetic material that determines your body's characteristics.